Interest rates have risen sharply across global markets, triggering significant selloffs in bond markets in countries including Japan, Korea, and the UK. Experts warn that bond markets are fragile and investors should not expect government interventions to ease shocks as in the past [1].

Gita Gopinath, a leading economist, attributes the inflationary pressures fueling rising interest rates to a combination of shifting demographics, high public debt levels, and intense capital demands emanating from the rapid growth of artificial intelligence technologies [1].

Meanwhile, in the US, Ocular Therapeutix is working to reduce blindness by lowering dropout rates in retinal disease treatments. Pravin Dugel, the company's CEO, said 40% of patients discontinue treatment in the first year, leading to blindness which costs over $66,000 annually per blind patient. He added that reducing the dropout rate by just 10% with their drug Axpaxli could prevent blindness for approximately 250,000 Americans, producing a substantial human and economic benefit [2].

Legal and regulatory pressures are mounting elsewhere in the US. Over 30 state attorneys general plan to sue Meta over harms linked to social media addiction, with tens of billions of dollars at stake [3]. The Justice Department is also investigating alleged exclusionary conduct in corn and soybean seed markets, targeting companies like Bayer and Corteva [3].

AI-driven productivity gains have sparked discussions of higher taxes on major tech firms, including Amazon, Nvidia, and Intel [3].

National security concerns remain high after the mayor of a Los Angeles suburb pleaded guilty last month to acting as an agent of the Chinese government, highlighting espionage issues [4]. In a related development, US Defense Secretary Pete Hegseth criticized European security partners while praising Asian allies at a recent Asia security forum, signaling a US strategic shift toward the Indo-Pacific and a softer stance on China [5].

Key recent developments include a May 28 interview with Ocular Therapeutix's CEO on reducing blindness, followed by Gopinath’s May 29 comments on the global bond market fragility and inflation drivers. On the same day, Bloomberg Intelligence previewed major lawsuits against social media companies and agricultural antitrust probes, while a podcast detailed the Chinese espionage case. Hegseth’s Indo-Pacific remarks came on May 30 [1, 2, 3, 4, 5].